American Journal of Orthopedic Research and Reviews https://escipub.org/index.php/AJORR <p>ISSN: 2637-4730<br />DOI:10.28933/AJORR</p> eSciPub LLC en-US American Journal of Orthopedic Research and Reviews 2637-4730 OSTEOPETROSIS: CLINICAL AND PHYSIOOGICAL FEATURES https://escipub.org/index.php/AJORR/article/view/179 <p>Introduction. Osteopetrosis (Albers-Schonberg disease) is an inherited bone disease characterized by the occurrence of osteoclast dysfunction, this causes bone density to increase, making it dense, hard and brittle. Goal. This is an integrative review in order to answer the following research question: what factors lead the individual to develop osteopothesis. Methodology. The search was performed in the following databases and online libraries: Pubmed, Medline and SciELO. Results and discussion. Osteopetrosis is a disease caused by gene mutations, which manifests itself mainly in two classifications: of recessive (malignant) and dominant (benign) type, its main diagnostic methods are radiographic analysis and histopathological exams. In both disease classifications some biochemical and physiological characteristics are altered as bone matrix components, genes, hormones and cells in the blood tissue causing both abnormal proliferation and the malfunctioning of cell members responsible for bone maintenance. Conclusion. Since it is a condition that has serious health consequences, osteopetrosis is still little known in the medical and social spheres. Thus, it is of fundamental importance that there is greater dissemination of research on this disease so that there is an increasingly early diagnosis and, thus, minimize its consequences and to establish an increasingly concise and efficient treatment plan.</p> Pionório D.L1*; Almeida M.F.L1; Dias. O.S.T1; Oliveira. G.B.M.1; Arruda S.H2 Copyright (c) 2021 https://creativecommons.org/licenses/by-nc/4.0 2020-09-16 2020-09-16 3 1 10 10 BIOPHYSICAL AND BIOCHEMICAL MODULATORS ASSOCIATED WITH HEALING OF THE OSSEOUS TISSUE https://escipub.org/index.php/AJORR/article/view/180 <p>Introduction: Fracture is a bone loss that can be discovered by pathological factors, congenital diseases, avitaminosis or even surgeries, and the cicatricial process as recovery of tissue stability. We have the possibility of assisting in the healing of the bone tissue of biochemical and biophysical modulators, from the use of hydroxyapathy, chitosone, ultrasound and cryotherapy.</p> <p>Objective: This literature review aimed to discuss the characteristics of bone tissue, its regeneration and the main biochemical and biophysical treatments without the use of auxiliary agents in the cicatricial process.</p> <p>Methodology: A research of data on PubMed, SciELO, LILACS, Journal of Cell Science and the Ministério da saúde was done through the keywords “Bone healing”, “Modulators” and its components in Portuguese and English, in the last 10 years. 92 articles were found, with 43 articles selected.</p> Mateus Porfírio Rodrigues 1*, Ingrid Larissa da Silva Laurindo2, Adalgiza Suellen da Silva Prado3, José Carlos Nogueira Nóbrega Júnior4, Jéssica Andréia Pereira Barbosa5, Marllon Alex Nascimento Santana6 Copyright (c) 2021 https://creativecommons.org/licenses/by-nc/4.0 2020-04-18 2020-04-18 3 1 11 11 PURE INTERNAL SUBTALAR DISLOCATION: ABOUT A CASE https://escipub.org/index.php/AJORR/article/view/181 <p>Subtalar dislocations are uncommon limb lesion representing 1% of all dislocations that occurs in polytraumatism context. We here report the case of a young patient presenting with sports-related internal astragalo-scapho-calcaneal dislocation. The patient underwent orthopedic treatment with good clinical and radiological outcome</p> J.Amghar, M. Yahyaoui, M. Benhammou, S. Aharram, O. Agoumi, A. Daoudi Copyright (c) 2021 https://creativecommons.org/licenses/by-nc/4.0 2020-02-04 2020-02-04 3 1 12 12 INTEREST OF THE FEMORALE FIXATION USING THE ULTRABOUTON IN THE ARTHROSCOPIC RECONSTRUCTION OF THE ACL (Anterior cruciate ligament) TECHNIQUE DIDT https://escipub.org/index.php/AJORR/article/view/182 <p>The previous chronic instability of the knee is a secondary progressive disease in the break of the previous crossed ligament (LCA) hiring the functional forecast of the lower and compromising limb sports activity.<br>The objective of our job is to assess the clinical results of the surgical treatment of the breaks of LCA according to the Technology of DIDT under arthroscopie with a femoral fixing by the system of the ultrabutton and to analyse the interest of this last in international series and magazine of literature<br>We report a series of 17 patients who introduced a previous chronic laxity, performed by arthroplasty of the hamstrings tendon (right internal DIDT – half tendon) arthroscopy of ACL, collected over a period of 12 months. Femoral fixation was provided by the endobutton system.<br>After a medium detachment of 8 months, and according to the score of objective International Knee Material Committee (IKDC) the total score of IKDC showed 91 % of our patients belonging to the group A, 7 % in the group B, 2 % to the group C and 0 % to the group D.</p> J.Amghar, M. Yahyaoui, M. Benhammou, S. Aharram, O. Agoumi, A. Daoudi Copyright (c) 2021 https://creativecommons.org/licenses/by-nc/4.0 2020-07-18 2020-07-18 3 1 13 13 Single-cell transcriptome analyses profile tissue macrophages in the human osteoarthritis https://escipub.org/index.php/AJORR/article/view/183 <p>Osteoarthritis (OA) has long been considered as a degenerative disease, but growing evidence suggests that inflammation plays a vital role in its pathogenesis. Unlike rheumatoid arthritis and other autoimmune diseases, inflammation in OA is chronic and in relatively low-grade, mainly mediated by the innate immune system, especially macrophages. However, due to its low abundance, there is a lack of systematic studies on macrophages in the OA condition. Here, we have used single-cell RNA sequencing analysis to gain insight into the heterogeneity and functional specialization of human knee macrophages. We also compared the gene expression profiles of macrophages in healthy people and OA patients, and found the characteristic changes of special macrophages in the OA knee. We believe that this in-depth understanding of the basis of OA inflammation will bring hope for the development of new therapies.</p> Jingbin Zhou1,2, Zhihong Zhao3, Chen He1, Feng Gao1, Yu Guo3, Feng Qu4, Yujie Liu1 Copyright (c) 2021 https://creativecommons.org/licenses/by-nc/4.0 2020-09-04 2020-09-04 3 1 14 14 OSTEOPOROSIS VERSUS TOOTH LOSS https://escipub.org/index.php/AJORR/article/view/184 <p>Osteoporosis is a common metabolic disease of the bones that increases bone fragility due to decreased bone mass and bad quality of bone, leading to an increased risk of bone fracture. This disease affects all the bones, including femurs/pelvis, spine, forearms, ribs, mandible, and maxillary bone. Periodontitis is an inflammation of the tissue around the teeth that results from infections and leads to tooth loss due to attachment loss and destruction of the alveolar bones around the teeth. Apart from Periodontitis, does Osteoporosis also lead to tooth loss? The purpose of this article is to answer this question. An electronic search of English language literature was conducted through PubMed, Medline, and Google scholar. The articles were selected through their topics and contents regarding osteoporosis, periodontitis, and tooth loss. The selected articles included cross-sectional, cohort, and review studies. Osteoporosis and periodontitis are multifactorial diseases and recent studies revealed a positive relation between periodontal disease and osteoporosis. In summary, as well as osteoporosis has an indirect correlation with tooth loss by periodontitis, it also has a direct relationship with tooth loss by decreasing mandibular and maxillary alveolar bone density. Not only Tooth loss could occur due to periodontitis, but also it has many other reasons, which with nowadays researches osteoporosis counts as one of them. Due to the effect of osteoporosis in the reduction of BMD and its relationship with periodontitis, it can both directly and indirectly result in tooth loss. Further well-controlled researches are required to clarify the inter-relationship between osteoporosis and tooth loss.</p> Samin Sirous1*, Iraj Salehi-Abari2 Copyright (c) 2021 https://creativecommons.org/licenses/by-nc/4.0 2020-09-04 2020-09-04 3 1 16 16 Semi-rigid lumbar spine fixation with PEEK rods as a treatment option for mono-segmental degenerative disk disease https://escipub.org/index.php/AJORR/article/view/185 <p>Long lasting back pain due to degenerative disc disease is one of the major reasons for reduced quality of life and work incapacity. In some of these patients conservative treatment will not improve back pain significantly. Therefore fusion surgery as a surgical option is offered to these patients. The main aim of this kind of treatment is the reduction of segmental motion leading to an improvement in pain. Rigid fixation leads to high fusion rates but may also contribute to stress shielding and adjacent segment degeneration.</p> <p>Therefore a semi-rigid stabilization with PEEK rods may be an option because it is associated with less implant related rigidity and is a less invasive procedure. The aim of this retrospective study was to evaluate the improvement in back pain after minimally invasive semi-rigid lumbar stabilization with screws and PEEK rods in 45 patients and to identify potential implant failures during a follow up of two years. Six weeks after surgery the patients showed a significant improvement in their back pain, which persisted during the whole observation time of two years (p&lt;0.01). All patients who were still in working life returned to their jobs without extended work incapacity. No implant related complication associated with the surgical procedure was detected. During the follow up time of two years no implant failure was observed.</p> Michael Winking MD, PhD1*, Mags Wigram PhD1 Copyright (c) 2021 https://creativecommons.org/licenses/by-nc/4.0 2020-09-04 2020-09-04 3 1 15 15