The validity of Protein S 100B in Mild Pediatric Head Trauma
- S100B, biomarker, CT Brain, mild head injuries, Pediatric.
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Background; S100B has been shown to be beneficial as a biomarker in the treatment of adults with mild traumatic brain injury (mTBI). The efficacy of S100B as a biomarker in children, on the other hand, has been a subject of debate. Aim and objectives; was to assess the validity of Protein S 100B in Mild Pediatric Head trauma. Subjects and methods; this was a prospective study, included 160 pediatric patients with mild head trauma presented to Emergency Department. Result; A highly significant correlation between Positive S100B protein and traumatic brain injury with S100B protein value 1554.1±84.0 ng/L. A100 had cutoff value for positive CT Brain finding above 987.5 ng/L, The sensitivity was 81.0%, the specificity was 75%%, the NPV was 86%, the PPV was 68%, and overall accuracy 77%. There was none statistical significant difference regarding severity of brain injury and S100 B (P = 0.225), Conclusion; Serum S100B levels cannot be used to substitute clinical examinations or CT scans in identifying pediatric patients with mild head injuries, but they can be used to identify low-risk kids to avoid excessive radiation exposure.
- Mohameda MA, Mahmoud S. El Desokya , Mohamed A. E. Elhamzawy, Evaluation of Prince of Wales Hospital score in predicting massive blood transfusion in trauma, Menoufia Med J 32:1246–125, DOI: 10.4103/mmj.mmj_302_18.
- Rutland-Brown W. “Incidence of traumatic brain injury in the United States, 2003.” The Journal of head trauma rehabilitation. 2006; 21: 544-548.?
- Hassan, Neven A. “Pattern of craniofacial injuries in patients admitted to Tanta University Hospital–Egypt.” Journal of forensic and legal medicine. 2010; 17: 26-32.?
- Pandor A. “Diagnostic management strategies for adults and children with minor head injury: a systematic review and an economic evaluation.” Health technology assessment [Winchester, England]. 2011; 15: 1.?
- Kuppermann N. “Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study.” The Lancet. 2009; 374 : 1160-1170.
- Melnick ER, Szlezak CM, Bentley SK, Dziura JD, Kotlyar S, Post LA. CT overuse for mild traumatic brain injury. Jt Comm J Qual Patient Saf. 2012; 38:483–9
- Pearce, Mark S. “Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study.” The Lancet. 2012; 380 : 499-505.?.
- Rodríguez-Rodríguez, Ana. “Role of S100B protein in urine and serum as an early predictor of mortality after severe traumatic brain injury in adults.” Clinica chimica acta. 2012; 414: 228-233.?
- Manzano, Sergio. “Diagnostic performance of S100B protein serum measurement in detecting intracranial injury in children with mild head trauma.” Emerg Med J. 2016; 33: 42-46.?
- Jagoda, Andy S. “Clinical policy: neuroimaging and decisionmaking in adult mild traumatic brain injury in the acute setting.” Journal of Emergency Nursing. 2009; 35: e5-e40.?
- Elbaih AH, Mohammed MA, Ali MA, Elshemaly AA, Mostafa MS. Validity of S100B protein as a prognostic tool in isolated severe head injuries in emergency patients. Egypt J Surg. 2020; 39: 795-806. Available from: http://www.ejs.eg.ne t/text.asp?2020/39/3/795/293680.
- Kristman V. L., Borg J., Godbolt A. K. Methodological issues and research recommendations for prognosis after mild traumatic brain injury: Results of the international collaboration on mild traumatic brain injury prognosis. Archives of Physical Medicine and Rehabilitation. 2014; 95:S265–S277. doi: 10.1016/j.apmr.2013.04.026.
- Fakhry T, Salah R, Gaber A. Full outline of unresponsiveness versus Glasgow coma scale in predicting mortality in paediatric trauma patients. Int Surg J 2019;6:2279-85
- Kelmendi F. M., Morina A. A., Mekaj A. Y., Blyta A., Alimehmeti R., Dragusha S., et al. Serum S100B Levels Can Predict Computed Tomography Findings in Paediatric Patients with Mild Head Injury. BioMed research international, 2018; 6954045. https://doi.org/10.1155/2018 /6954045.
- Manzano S, Holzinger IB, Kellenberger CJ. Diagnostic performance of S100B protein serum measurement in detecting intracranial injury in children with mild head trauma, Emerg Med J. 2016; 33: 42–46.
- Egea-Guerrero JJ, Murillo-Cabezas F, Gordillo-Escobar E, Rodríguez-Rodríguez A, Enamorado-Enamorado J, Revuelto-Rey J et al. S100B protein may detect brain death development after severe traumatic brain injury. J Neurotrauma. 2013; 30:1762–1769.
- Shakeri M, Mahdkhah A, Panahi F. S100B protein as a post-traumatic biomarker for prediction of brain death in association with patient outcomes. Arch Trauma Res. 2013; 2:76–80.
- Kleindienst A, Grunbeck F, Buslei R, Emtmann I, Buchfelder M. Intraperitoneal treatment with S100B enhances hippocampal neurogenesis in juvenile mice and after experimental brain injury. Acta Neurochir [Wien]. 2013; 155:1351–1360.
- Bouvier D, Fournier M, Dauphin JB. Serum S100B determination in the management of pediatric mild traumatic brain injury. Clin Chem 2012;58:1116–22.
- Abdelfattah E, Marwa N, Mohamed A, Khaled F, Abdelraouf. Prognostic Value of Protein S100B in Traumatic Brain Injury, The Egyptian Journal of Critical Care Medicine, 2020; 7: 80-85 doi: 10.1097/EJ9.0000000000000016
- Andrade FP., Montoro N, Roberto O, Renan L, Gabriela F, Luana G, et al. Pediatric minor head trauma: do cranial CT scans change the therapeutic approach?. Clinics. 2016; 71: 606-610. https://doi.org/10.6061/clinic s/2016[ 10]09.