Translational Medicine and Autologous Fat Transfer: From bench to bedside. Regenerative and proliferative potential of adipose tissue
- Regenerative medicine, translational medicine, lipofilling, fat grafting, adipose-derived-stem-cells, fat graft survival, fat graft processing, maxillofacial surgery, soft tissue reconstruction, stem cells, bench to bedside
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Aim: Autologous fat transfer (AFT) for the correction of maxillofacial defects was first reported at the end of the 19th century. AFT was introduced as a way of improving facial esthetics and in the last few years has expanded into applications in craniomaxillofacial reconstructive surgery and regenerative therapy. This protocol is part of translational medicine. The aim of translational medicine, or translational science, is to combine disciplines, resources, expertise, and techniques based on three main pillars: bench, bedside, and community. The primary goals to coalesce assets of various natures to significantly improve the global healthcare system. AFT is thus part of translational medicine in tissue healing, regeneration and augmentation.
Methods: Several techniques have been suggested for harvesting and grafting the fat. The Authors follow Coleman’s technique with centrifugation and infiltration using different types and sizes of cannulas.
Conclusion: This review provides a fairly comprehensive summary of the many exciting possibilities that exist in the field of facial fat grafting. Five clinical cases are presented and discussed. Translational medicine is the basis of this new reconstructive and regenerative field of science and research.
- Coleman SR. Facial recontouring with lipostructure. Clin Plast Surg 1997;24(2):347–367
- Coleman SR. Structural fat grafts: the ideal ?ller? Clin Plast Surg 2001;28(1):111–119
- Coleman SR, ed. Structural Fat Grafting. Saint Louis, MO: Quality Medical Publishing Inc; 2004
- Rigotti G, Marchi A, Sbarbati A. Adipose-derived mesenchymal stem cells: past, present, and future. Aesthetic Plast Surg 2009; 33(3):271–273
- Strem BM, Hicok KC, Zhu M, et al. Multipotential differentiation of adipose tissue-derived stem cells. Keio J Med 2005;54(3):132–141
- Fraser JK, Wulur I, Alfonso Z, Hedrick MH. Fat tissue: an underap- preciated source of stem cells for biotechnology. Trends Biotechnol 2006;24(4):150–154
- Moseley TA, Zhu M, Hedrick MH. Adipose-derived stem and progenitor cells as ?llers in plastic and reconstructive surgery. Plast Reconstr Surg 2006;118(3, Suppl):121S–128S
- Clauser L.et al.Structural fat grafting: facial volumetric restoration in complex reconstructive surgery. J Craniofac Surg 2011;22(5):1695–1701
- Clauser L.et al. Integrated reconstructive strategies for treating the anophthalmic orbit. J Craniomaxillofac Surg 2004;32(5):279–290
- Clauser L et al. Optimizing maxillofacial and craniofacial results. Presented at: American Society of Plastic Surgeons Annual Meeting; October 2009; Seattle, WA
- Clauser L. Optimizing maxillofacial and craniofacial results. In: Coleman SR, Mazzola RF, eds. Fat Injection From Filling to Regeneration. Saint Louis, MO: Quality Medical Publishing Inc; 2009: 475–500
- Clauser L. et al Autologous fat transfer for facial augmentation and regeneration: Role of Mesenchymal stem cells-. Atlas of the Oral and Maxillofacial Surgery Clinics,Editors: Bagheri,H.Khan,B.Bohuli – Elsevier 2018
- Clauser L. Facial Lipostructure: an overview l. American Journal of Surgical Research and Reviews, 2021, 4:20 doi.org/10.28933/ajsrr-2021-05-1206
- Clauser L. Autologous Facial Fat Transfer: Soft Tissue Augmentation and Regenerative Therapy. J of Craniofacial Surgery, 31, 7 – October 2020, 1879 – 1882.
- Giugliano C, Benitez S, Wisnia P, Sorolla JP, Acosta S, Andrades P. Liposuction and lipoinjection treatment for congenital and ac- quired lipodystrophies in children. Plast Reconstr Surg 2009; 124(1):134–143
- Coleman SR, Saboeiro A, Sengelmann R. A comparison of lipoa- trophy and aging: volume de?cits in the face. Aesthetic Plast Surg 2009;33(1):14–21
- Foyatier JL, Mojallal A, Voulliaume D, Comparin J-P. [Clinical evaluation of structural fat tissue graft (Lipostructure) in volumetric facial restoration with face-lift. About 100 cases]. Ann Chir Plast Esthet 2004;49(5):437–455
- Bucky LP, Kanchwala SK. The role of autologous fat and alternative ?llers in the aging face. Plast Reconstr Surg 2007;120(6, Suppl):89S–97S
- Mojallal A, Foyatier JL. [The effect of different factors on the survival of transplanted adipocytes]. Ann Chir Plast Esthet 2004; 49(5):426–436
- Tonnard P,Verpaele A, et al. Nanofat Grating: Basic research and Clinical applications.Plast Reconstr. Surg. 2013;132(4):1017-1026
- Tonnard P,Verpaele A,Carvas M, Fat Grating for facial rejuvenation with nanofat grafts
- Clin Plast Surg 2020 Jan:47(1) 53-62 doi: 10.1016/j.cps.2019.08.006
- Kawamoto HK. Fat injection and craniofacial surgery. In: Coleman SR, Mazzola RF, eds. Fat Injection From Filling to Regeneration. Saint Louis, MO: Quality Medical Publishing Inc; 2009:447–474
- Coleman SR. Long-term survival of fat transplants: controlled demonstrations. Aesthetic Plast Surg 1995;19(5):421–425
- Sarkarat F.,Roozbbeh K. Fat grat with growth factors.Atlas oral and Maxillofacial Surgery Clin.N Am 26(2018) 33-39 doi.org/10.1016/j.cxom.2017.10.003
- Gutowski KA; ASPS Fat Graft Task Force. Current applications and safety of autologous fat grafts: a report of the ASPS fat graft task force. Plast Reconstr Surg 2009;124(1):272–280
- Glasgold RA, Glasgold MJ, Lam SM. Complications following fat transfer. Oral Maxillofac Surg Clin North Am 2009;21(1):53–58, vi
- Lee DH, Yang HN, Kim JC, Shyn KH. Sudden unilateral visual loss and brain infarction after autologous fat injection into nasolabial groove. Br J Ophthalmol 1996;80(11):1026–1027
- Caviggioli F, Klinger F, Villani F, Fossati C, Vinci V, Klinger M. Correction of cicatricial ectropion by autologous fat graft. Aesthet- ic Plast Surg 2008;32(3):555–557
- Zuk PA. The adipose-derived stem cell: looking back and looking ahead. Mol Biol Cell 2010;21(11):1783–1787
- Rigotti G, Marchi A, Galiè M, et al. Clinical treatment of radiother- apy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells. Plast Reconstr Surg 2007;119(5):1409–1422, discussion 1423–1424
- Kokai LE, Rubin JP, Marra KG. The potential of adipose-derived adult stem cells as a source of neuronal progenitor cells. Plast Reconstr Surg 2005;116(5):1453–1460
- Shih L, et al. Semin Plast Surg. 2020. PMID: 3207157