Prostate stromal tumour: case reports and review of literature
- Sarcoma; Stromal tum-our; Prostate cancer; STUMP
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Prostate cancer is a common malignancy in men; however, sarcoma of the prostate is an uncommon variant. Sarcoma of the prostate occurs in all age groups with rhabdomyosarcoma being more common in children while leiomyosarcoma occurs more in the older adults. Stromal tumour of uncertain malignant potential (STUMP) occurs in adults. Modalities of treatment include surgery, radiotherapy and chemotherapy used singly or in combination, but all report poor long term survival despite treatment selected. We present 2 cases of prostate stromal tumours.
We present two patients in their fourth decade who presented with acute urinary retention. Computed tomography scan was performed in both cases and showed a large tumour arising from the prostate. Prostate specific antigen was less than 4ng/ml in the two cases and core needle biopsy performed and samples taken for histology. The histology reports showed embryonal carcinoma and STUMP in the first and second cases respectively.
Prostate sarcomas are uncommon but may pursue aggressive clinical course while STUMP has a variable course. Early diagnosis and use of combined modalities of treatment may be required to improve survival.
- Tetu B, Srigley JR, Bostwick DG. Soft tissue tumours. In: Bostwick DG, editor. Pathology of the prostate. New York: Churchill Livingstone; 1990. p. 117.
- Varghese SL, Grossfeld GD. The prostatic gland: malignancies other than adenocarcino- mas. Radiologic Clinics of North America. 2000; 38(1):179-202.
- Morse M, Whitmore W. Genitourinary sarcomas in adults. Surgical Management of Soft Tissue Sarcomas Philadelphia, PA: Lea and Febiger. 1989:189-207.
- Sexton WJ, Lance RE, Reyes AO, Pisters PW, Tu S-M, Pisters LL. Adult prostate sarcoma: the MD Anderson Cancer Center experience. The Journal of Urology. 2001;166(2):521-5.
- Herawi M, Epstein J I. Specialized stromal tumors of the prostate: a clinicopathologic study of 50 cases. Am J Surg Pathol 2006;30(6): 694-704.
- Gaudin P B, Rosai J, Epstein J I. Sarcomas and related proliferative lesions of specialized prostatic stroma: a clinicopathologic study of 22 cases. Am J Surg Pathol 1998;22(2):148-62.
- Wang X, Liu L, Tang H, Rao Z, Zhan W, Li X, et al. Twenty-five cases of adult prostate sarcoma treated at a high-volume institution from 1989 to 2009. Urology. 2013;82(1):160-5.
- Musser JE, Assel M, Mashni JW, Sjoberg DD, Russo P. Adult prostate sarcoma: the Memorial Sloan Kettering experience. Urology. 2014;84 (3):624-8.
- Waring PM, Newland RC. Prostatic embryonal rhabdomyosarcoma in adults. A clinicopatho- logic review. Cancer. 1992;69(3):755-62.
- Bisceglia M, Magro G, Carosi I, Cannazza V, Ben Dor D. Primary embryonal rhabdomyo- sarcoma of the prostate in adults: report of a case and review of the literature. International Journal of Surgical Pathology. 2011;19(6): 831- 7.
- Janet NL, May A-W, Akins RS. Sarcoma of the prostate: a single institutional review. American Journal of Clinical Oncology. 2009;32(1):27-9.
- Melicow M, Pelton T, Fish G. Sarcoma of the prostate gland: review of literature; table of classification; report of four cases. The Journal of Urology. 1943;49(5):675-707.
- Andreou A, Whitten C, MacVicar D, Fisher C, Sohaib A. Imaging appearance of sarcomas of the prostate. Cancer Imaging. 2013;13(2):228.
- Chang JM, Lee HJ, Lee S, Byun S-S, Choe G, Kim S, et al. Unusual tumours involving the prostate: radiological–pathological findings. The British Journal of Radiology. 2008;81(971): 907- 15.
- Agrons GA, Wagner BJ, Lonergan GJ, Dickey GE, Kaufman MS. From the archives of the AFIP. Genitourinary rhabdomyosarcoma in children: radiologic-pathologic correlation. Radi- ographics. 1997;17(4):919-37.
- Vandoros GP, Manolidis T, Karamouzis MV, Gkermpesi M, Lambropoulou M, Papatsoris AG, et al. Leiomyosarcoma of the prostate: case report and review of 54 previously published cases. Sarcoma. 2008;2008.
- De Berardinis E, Busetto GM, Antonini G, Giovannone R, Di Placido M, Maglioccia FM, et al. Incidental prostatic Stromal Tumor of Un- certain Malignant Potential (STUMP): Histopa- thological and immunohistochemical findings. Urologia Journal. 2012;79(1):65-.
- De Bari B, Stish B, Ball MW, Habboush Y, Sargos P, Krengli M, et al. Adult prostatic sarcoma: a contemporary multicenter Rare Cancer Network study. The Prostate. 2017; 77 (10):1160-6.
- Ciammella P, Galeandro M, D’Abbiero N, Palmieri T, Donini E, Iotti C. Prostate embryonal rhabdomyosarcoma in adults: Case report and review of literature. Reports of Practical Oncology & Radiotherapy. 2013;18(5):310-5.
- Konno M, Mitsuzuka K, Yamada S, Yamashita S, Kaiho Y, Ito A, et al. A case of adult metastatic rhabdomyosarcoma of the prostate cured by long-term chemotherapy with local radiation. Urologia Internationalis. 2019;102(1):118-21.
- Dotan ZA, Tal R, Golijanin D, Snyder ME, Antonescu C, Brennan MF, et al. Adult genitourinary sarcoma: the 25-year Memorial Sloan-Kettering experience. The Journal of Urology. 2006;176(5):2033-9.