Vol. 3 No. 1 (2020): International Journal of Aging Research
Research Articles

Studying the Relation between lipid profile and HbA1c in elderly patients with Type 2 Diabetes

Marwa Abdel azim Abdel Gawad and Hend F Mahmoud
Faculty of Medicine, Department of Geriatrics and Gerontology, Ain Shams University, Cairo, Egypt.
Keywords
  • Type 2 diabetes, elderly patients, HbA1c, lipid profile.
How to Cite
Marwa Abdel azim Abdel Gawad and Hend F Mahmoud. (2020). Studying the Relation between lipid profile and HbA1c in elderly patients with Type 2 Diabetes. International Journal of Aging Research, 3(1), 55. https://doi.org/10.28933/ijoar-2020-01-1605

Abstract

Introduction: Diabetes mellitus is characterized by chronic hyperglycemia with disturbances in carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action or both. Glucose and lipid metabolism are linked to each other. It is well known that dyslipidemia is considered a major risk factor for macrovascular complications in patients with type-2 diabetes mellitus. Recently, obesity-related metabolic syndrome has received widespread attention. The aim of the current study was to find out the correlation between HbA1c, lipid profile and BMI of elderly patients with type 2 Diabetes mellitus.
Methods: A cross-sectional observational study was conducted in a sample consists of one hundred and sixty elderly patients with type 2 diabetes. Glycemic control, lipid profile, body mass index (BMI) were assessed.
Results: There was a significant positive correlation between HbA1c and FBS with total cholesterol, LDL and triglycerides and a significant negative correlation with HDL. Also, there was a significant positive correlation between HbA1c and FBS with BMI.
Conclusion: Increased levels of HbA1c, is associated with dyslipidemia and increased BMI

References

  1. Bennett HP, Knowler WC, Definition, Classification of Diabetes Mellitus and Glucose Homeostasis. In CR Kahn, GC Weir, GL King, AC Moses, RJ Smith and AM Jacobson editors. Joslin’s Diabetes Mellitus, Philadelphia: LWW; 200,331.
  2. Powers AC (2015): Diabetes Mellitus: Complications. In DL Kasper, AS Fauci, DL Longo, SL Hauser, JL Jameson and J Loscalzo editors. Harrison’s Principles of Internal Medicine. New York: McGraw-Hill Education; p2399.
  3. Diabetes: facts and figures [Internet]. International Diabetes Federation. [cited 2016Jul14]. Available from: http://www. idf.org/about-diabetes/facts-figures.
  4. Mukhopadhyay J, Kanjilal S, Biswas M. (2013): Diabetic dyslipidemia-priorities and targets in India. [Internet]. http://www.apiindia.org/content_mu_2010.html. 2013 [cited 23 August 2016].
  5. Selvin E. Meta-Analysis (2004): Glycosylated hemoglobin and cardiovascular disease in diabetes mellitus. Annals of Internal Medicine; 141:421.
  6. Klaus G. Parhofer (2015): Interaction between Glucose and Lipid Metabolism: More than Diabetic Dyslipidemia. Diabetes Metab J; 39(5): 353–362.
  7. Lodha R, Lal R, Biyani S (2016): HbA1c as screening biomarker of dyslipidemia in type 2 diabetes mellitus patients. Scholar journal of applied medicsl sciences; 4:1600-1602.
  8. Ning XJ, Zhan CQ, Yang YH, et al. (2014): Secular trends in prevalence of overweight and obesity among adults in rural Tianjin, china from 1991 to 2011: a population- based study. PLOS ONE; 9(12):5-16.
  9. de Mutsert R, Sun Q, Willett WC, Hu FB, van Dam RM (2014): Overweight in early adulthood, adult weight change, and risk of type 2 diabetes, cardiovascular diseases, and certain cancers in men: a cohort study. Am J Epidemiol;179(11):1353–1365.
  10. Ikenna CE, Medea I, Ashish K, Arnold von E, Daiana S, Margaret WG, et al. (2016): Air pollution and diabetes association: Modification by type 2 diabetes genetic risk score. Environment International; 94:263–271.
  11. Shamai L, Lurix E, Shen M, Novaro GM, Szomstein S, Rosenthal R, Hernandez AV, Asher CR (2011): Association of body mass index and lipid profiles: evaluation of a broad spectrum of body mass index patients including the morbidly obese. Obes Surg; 21(1):42-7.
  12. Sheth J, Shah A, Sheth F, Trivedi S, Nabar N, Shah N et al. (2015): The association of dyslipidemia and obesity with glycated hemoglobin. Clinical Diabetes and Endocrinology;1(1).
  13. Senthilkumar N, Anadasayanam A, Senthilvelu S, Rashid M (2016): Correlation observation between HbA1C and Lipid profile in Type II Diabetes Mellitus Out-Patients. International Journal of Pharma Research and Review; 5:9-20.
  14. Abd Elkarim A. Abdrabo et al. (2016): Role of glycemic control on lipids profile in diabetic sudanese patients. Journal of Science; 6:208-212.
  15. Neelam Agrawal, Mukesh Kumar Agrawal, Tannu Kumari, Sunil Kumar (2017): Correlation between body mass index and blood glucose levels in Jharkhand population. International Journal of Contemporary Medical Research; 4(8):1633-1636.
  16. Mahato RV, Gyawali P, Raut P, Regmi P, Singh K, Pandeya DR, et al. (2011): Association between glycaemic control and serum lipid profile in type 2 diabetic patients: Glycated haemoglobin as a dual biomarker. Biomedical Research; 22(3):375–80
  17. Soodini GR (2004): Adiponectin and leptin in relation to insulin sensitivity. Metab Syndr Relat Disord; 2(2):114-23.
  18. McTernan CL, McTernan PG, Harte AL, Levick PL, Barnett AH, Kumar SLancet (2002): Resistin, central obesity, and type 2 diabetes; 359(9300):46-7.
  19. Tames FJ, Mackness MI, Arrol S, Laing I, Durrington PN (1992): Non-enzymatic glycation of apolipoprotein B in the sera of diabetic and non-diabetic subjects. Atherosclerosis; 93:237–244.
  20. Yan Z, Liu Y, Huang H (2012): Association of glycosylated hemoglobin level with lipid ratio and individual lipids in type 2 diabetic patients. Asian Pacific Journal of Tropical Medicine; 5:469-471.
  21. Saurabh Sultania, Dhanakar Thakur, Malini Kulshreshtha (2017): Study of lipid profile in type 2 diabetes mellitus patients and its correlation with HbA1c. International Journal of Contemporary Medical Research;4(2):437-439.
  22. Hammed IK, Abed BA, Rashid NF (2012): Glycated haemoglobin as a dual biomarker Association between HbA1c and dyslipidemia in type 2 diabetic patients. J Fac Med Baghdad; 54(1):88–92.
  23. Singh AK, Singh SK, Singh N, Agrawal N, Gopal K (2011): Obesity and dyslipidemia. Int J Biol Med Res; 2(3):824–8.