Vol. 3 No. 4 (2020): International Journal of Aging Research
Review Articles

Alzheimer’s Disease & Dementia-From Pathophysiology To Clinic

Paulo Roberto de Brito Marques
Professor Doctor, Director of the Discipline of Neurology, Faculdade de Ciências Médicas (FCM), University of Pernambuco (UPE). Preceptor of the Neurology Residency at the Universitary Hospital Oswaldo Cruz of FCM-UPE. Coordinator of the Center for Studies in Neurology of the Behavior of the Neurology Discipline at FCM-UPE. Member of the Alzheimer \Parkinson Committee for Technical-Scientific Advice and Honorary Provision – of the Pharmaceutical Assistance Management of the Pernambuco State Health Department.


  • Alzheimer’s Disease,Dementia, Pathophysiology, Clinic

How to Cite

Paulo Roberto de Brito Marques. (2020). Alzheimer’s Disease & Dementia-From Pathophysiology To Clinic. International Journal of Aging Research, 3(4), 70. https://doi.org/10.28933/ijoar-2020-08-1005


Dementia is a syndrome that occurs due to the difficulty of a patient in doing his cognitive and instrumental activities of daily life with the same performance as before, bringing him losses. This syndrome is caused by numerous primary and secondary etiologies. The most common primary cause of dementia is Alzheimer’s disease (AD), which reaches almost 50% of dementia cases. The DA it consists of biological fragments of the amyloid precursor protein that are deposited in the brain 10 years or more, before the first symptoms appear. The period before the onset of symptoms is called the preclinical stage. The transition between the silence of symptoms and their appearance, usually due to memory loss for recent events, is known as the prodromal phase. Continuing the pathophysiological process, the stage of mild dementia takes place, when the patient has one more cognitive component associated with memory loss; follows the moderate, severe, profound and terminal phase of dementia.


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