Vol. 3 No. 5 (2020): International Journal of Aging Research
Research Articles

Exergaming improves functional fitness in MCI patients. Does the APOE genotype moderate the outcome?

Anthoula C. Tsolaki1,2*, Magda Tsolaki2, Niki Pandria1, Eftychia Lazarou2, Olympia Gkatzima3, Vasiliki Zilidou1, Maria Karagianni1, Zafiroura Iakovidou- Kritsi4, Vasilios K. Kimiskidis2, Panagiotis D. Bamidis1
1Medical Physics Laboratory, School of Medicine, Aristotle University of Thessaloniki, Greece., orcid: 0000-0002-5563-7776, orcid: 0000-0002-4859-6996, orcid: 0000-0002-4492-4382, orcid: 0000-0002-7130-5739, orcid: 0000-0002-9936-5805. 21st Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki.Greece, orcid: 0000-0003-1272-9782, orcid:0000-0002-2072-8010, orcid: 0000-0002-3335-3019. 3Panhellenic Institute of Neurodegenerative Diseases, Thessaloniki, Greece, orcid: 0000-0002-2415-0498. 4Laboratory of Medical Biology-Genetics Department, School of Medicine, Aristotle University of Thessaloniki, Greece, orcid: 0000-0001-6800-2369.


  • Mild Cognitive Impairment; APOEε4; Exergaming; Functional fitness; Physical Exercise; Fullerton

How to Cite

Anthoula C. Tsolaki1,2*, Magda Tsolaki2, Niki Pandria1, Eftychia Lazarou2, Olympia Gkatzima3, Vasiliki Zilidou1, Maria Karagianni1, Zafiroura Iakovidou- Kritsi4, Vasilios K. Kimiskidis2, Panagiotis D. Bamidis1. (2020). Exergaming improves functional fitness in MCI patients. Does the APOE genotype moderate the outcome?. International Journal of Aging Research, 3(5), 74. https://doi.org/10.28933/ijoar-2020-11-2105


Objectives: Mild cognitive impairment could be defined as the condition between healthy aging and dementia. MCI patients seem to retain the neuroplasticity to benefit from Physical Exercise (PE) interventions delaying the progression to dementia. The present study investigates the impact of PE via “Exergaming” on the functional fitness of MCI adults, depending on the presence of the APOE?4 allele.

Methods: 159 MCI participants were recruited. They were separated to two groups (performing PE or not). The Fullerton Functional Test was used as a primary outcome measure in two-time points (prior to and after PE).

Results: The Active group showed more considerable improvement compared to the Passive group in all Fullerton components despite the presence of APOE?4.

Discussion: ?? via exergaming has a beneficial functional effect in MCI patients, whether carrying the APOE?4 allele or not.


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