Vol. 2 No. 1 (2019): International Journal of Aging Research
Review Articles

Neuroprotective Effect of Flavonoids: A Systematic Review

Divya Singh1 and Sukanya Hembrom2
1Ph.D scholar of Department of Biochemistry and Biochemical Engineering, Jacob School of Biotechnology and Bioengineering, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad, Uttar Pradesh, India 2Gust faculty of Department of Microbiology, Dr. Shyama Prasad Mukherjee University, Ranchi, India


  • Flavonoids, neuro-inflammatory, neurodegeneration, Rutin, Apigenin, Hesperidin, Kaempferol, Naringenin, Anthocyanins, Naringin, Baicalein, Catechin

How to Cite

Divya Singh1 and Sukanya Hembrom2. (2019). Neuroprotective Effect of Flavonoids: A Systematic Review. International Journal of Aging Research, 2(1), 26. https://doi.org/10.28933/ijoar-2018-11-0906


Neurodegenerative disorders such as Parkinson’s and Alzheimer’s disease are underpinned by neuronal damage corollary to the cascade of events pitched in by neuron inflammatory processes. Increase in cases of neurodegenerative diseases and ageing population indicates the need for developing new strategies to prevent or treat brain dysfunction and associated cognitive decline. Flavonoids have been documented for various health promoting effects. They exert multiple neuroprotective actions within the brain, such as protection of neurons from neurotoxins, suppression of neuron-inflammation and thus improve memory, learning and cognitive function. Two processes appear to be the basis of these effects. Firstly, they promote neuronal survival and synaptic plasticity by inhibition of apopotosis triggered by neurotoxic species due to interaction with critical protein and lipid kinase signaling cascades. Secondly they induce beneficial effects on the vascular system leading to changes in cerebrovascular blood flow capable of causing angiogenesis, neurogenesis and neuronal morphology. Limiting neurodegeneration and prevention or reversal of age-dependent loss in cognitive performance is possible by consumption of flavonoids-rich food throughout life. Thus flavonoids are strong candidates of being an important precursor molecule in the development of new generation of brain enhancing drugs. The present review accentuates current information on neuroprotective effects of flavonoids.


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