Vol. 2 No. 3 (2019): International Journal of Aging Research
Research Articles

Alzheimer´s Disease and Age-related Macular Degeneration could simultaneously be treated or prevented with a single therapeutic intervention

Arturo Solís Herrera, MD, PhD.
Human Photosynthesis® Research Centre Aguascalientes2000, México
Keywords
  • AD, AMD, Melanin, hydrogen, energy, glucose.
How to Cite
Arturo Solís Herrera, MD, PhD. (2019). Alzheimer´s Disease and Age-related Macular Degeneration could simultaneously be treated or prevented with a single therapeutic intervention. International Journal of Aging Research, 2(3), 37. https://doi.org/10.28933/ijoar-2019-04-0805

Abstract

Alzheimer ´s diseases becomes the most common type of dementia in the world. There is more of 5.4 million AD patients in America, more than 6 million patients in China, and 35.6 million patients worldwide. AD and other dementias worldwide will increase to 67.5 million by 2030 and 115.4 million by 2050. In the aging population, two of the most common neurodegenerative diseases, AD and AMD, could simultaneously treated or prevented with single therapeutic intervention.

References

1. Tielsch, JM. Javitt, JC. Coleman, A. Katz, J. Sommer, A. The prevalence of blindness and visual impairment among nursing home residents in Baltimore. N Engl J M 1995: 332 (18): 1205-1209
2. Hinton, DR. Sadun, AA. Blanks, JC. Miller, CA. Optic-nerve degeneration in Alzheimer´s disease. N Engl J Med 1986: 315(8): 485-487
3. Anstey, KJ. Von Sanden, C. Salim, A. O´Kearney R. Smoking as risk factor for dementia and cognitive decline: a meta-analysis of prospective studies. AM J Epidemiol, 2007; 166(4): 367-378.
4. Wong, TY. Klein, R. Sun, C. et al. Atherosclerosis Risk in Communities Study. Age-related macular degeneration and risk for stroke. Ann Intern Med 2006; 145(2): 98-106
5. Ding, Jindong. Mace, John. Mace, Brian E. Rolf, Herman. Sullivan, Patrick. Bowes Rickman, Catherine, Targeting Age-related Macular Degeneration with Alzheimer’s disease-based immunotherapies. Anti-amyloid β antibody attenuates pathologies in and Age-related Macular degeneration Mouse Model. Vision Res 2008 February; 48(3): 339-345.
6. Wade. Lizzie. Light skin may be legacy of native American ancestors. Science, January 25, 2019. Vol. 363, Issue 6425, pp. 333.
7. Solis-Herrera, A. Arias-Esparza, MC. Solis-Arias, RI, et al. The unexpected capacity of melanin to dissociate the water molecule fills the gap between the life before and after ATP. Biomed Res. 2010: 21(2).pp. 224-226
8. Solis-Herrera, A. Arias-Esparza, MC. Ashraf, Ghulam MD.Zamyatnin Jr, Andrey A. Aliev, Gjumrakch. Beyond Mitochondria, what Would be the energy source of the cell? CNS Agents in Med Chem, 2015, 15, 32-41.
9. Vastrik I et al, (2007) Reactome: a knowledge base of biologic pathways and processes. Genome Biology 8; R39
10. Jatoi, Aminah. Loprinzi, Charles L. Sloan, Jeffrey. Goldberg, Richard M. Is ATP (adenosine-5´-triphosphate), like STP® a performance-enhancing additive for the tanks of cancer patients? J Nat Can Inst, Vol 92, No. 4, February 16, 2000.
11. Zhang, Meijuan, Li, Wenjin. Nlu, Guangming. Leak, Rehana K. Chen, Jun. Zhang, Feng. ATP induces mild hypothermia in rats but has a strikingly detrimental impact on focal cerebral ischemia. J Cerebral Blood Flow & Met (2013), e1-e10
12. Richer C, Schweizer M, Cossarizza A, Francheschi C.Control of apoptosis by the cellular ATP level. FEBS Letters, 1996; 378: 107-110
13. Baker, Michelle L. Wang, Jie Jin. Rogers, Sophie. Klein, Ronald. Kuller, Lewis H. Larsen, Emily K. Wong, Tien Yin. Early Age-related Macular degeneration, Cognitive Function and Dementia. The Cardiovascular Health Study. Arch. Ophthalmol, 2009; 127 (5): 667-673
14. Stephenson, Jodie. Nutma, Erick. Van der Valk, Paul. Amor, Sandra. Inflammation in CNS neurodegenerative diseases. Immunology, 2018 154, 204-2019
15. Miguel J. Quintaniha, A.T. Weber, H. CRC Handbook of free radicals and Antioxidants, Vol !. CRC Press, Boca Raton (1989), pp 209-223
16. Parihar, Mordhwaj S. Brewer, Gregory J. Mitoenergetic failure in Alzheimer´s Disease. Am J Physiol Cell Physiol 292: C8- C23, 2007- doi: 10.1152/ajpcell.00232.2006
17. Zoltan Bay, John Avery. Szent-Györgyi, Albert. On the energy transfer in biological systems. Institute for muscle Research at the Marine, Woods Hole, Massachusetts. Communicated Sept 15 1951.
18. Szent-Györgyi, Albert. Bioenergetics. Science. 2 Nov. 1956, Vol. 124, No. 3227.pp873-875