International Journal of Aging Research
Vol. 2 No. 5 (2019): International Journal of Aging Research
Research Articles

Use and preventive value of metformin in geriatric women with polycystic ovary syndrome

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  • Jazmín Abril Pérez Aguilar, Alejandra Niño Herrera, Guillermo Muñoz Zurita
Jazmín Abril Pérez Aguilar, Alejandra Niño Herrera, Guillermo Muñoz Zurita
Facultad de Medicina Benemérita Universidad Autónoma de Puebla
DOI: https://doi.org/10.28933/ijoar-2019-11-2605
Keywords
  • Metformin, Geriatrics, Syndrome, Ovaries, Polycystic
How to Cite
Jazmín Abril Pérez Aguilar, Alejandra Niño Herrera, Guillermo Muñoz Zurita. (2019). Use and preventive value of metformin in geriatric women with polycystic ovary syndrome. International Journal of Aging Research, 2(5). https://doi.org/10.28933/ijoar-2019-11-2605
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Abstract

Objective: To establish the effects of long-term use and preventive value of metformin in geriatric women with PCOS.

Methods: A search of published review articles was carried out in sites such as NCBI, ScienceDirect, Elsevier, Springer, Wolters Kluwer, among others, using the key words: “polycystic ovary syndrome”, “PCOS”, “Polycystic ovary syndrome and metformin”, “effects of metformin and PCOS“,” insulin resistance and metformin “and” long-term sequelae of polycystic ovarian syndrome“.

Results: We retrospectively analyzed data specific to the randomized clinical trial of Pedersen et al. 2017, to determine the impact that treatment had for twelve months with metformin in three specific variables: weight, total cholesterol and HDL. The study was conducted in 40 Caucasian women from 18 to 39 years of age, with a fixed dose of metformin (2 g / day for 12 months), who met the Rotterdam criteria for PCOS in their genetic variant MATE1 with SOP7.

Conclusions: It was confirmed that the establishment of twelve-month treatment with metformin in the randomized clinical trial of Pedersen et al. 2017 had a significant effect on the three specific variables: weight, total cholesterol and HDL.

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